OPI Hand and Nail Treatment. OPI Avoplex high intensity hand and nail cream - Cold weather, overexposure to the elements, and everyday wear and tear can make even the softest hands a little rough – but when “a little rough” turns into extremely dry, severely overworked hands, Avoplex High-Intensity Hand & Nail Cream from OPI offers intense relief. Avoplex High-Intensity Hand & Nail Cream is packed with deep-penetrating protein peptides; an exclusive, ultra-moisturizing blend of Shea, Cocoa, Avocado and Almond butters; and OPI’s Advanced Avocado Lipid Complex. This rich, soothing moisturizer provides maximum hydration; increases skin elasticity and nail flexibility; and nourishes and protects hands and nails